This series is coordinated by Allen F. Shaughnessy, PharmD, assistant medical editor. As an alternative option to current pharmacological AOTs, OSH may address an existing clinical gap in weight management. Study selection and data extraction: monograph. Only human studies were used for drug interaction, efficacy, and safety data. See additional information. In order to provide you with relevant and meaningful content we need to know more about you. Communication with your healthcare provider is key in helping to prevent drug interactions. Tell your doctor all medications and supplements you use. MeSH This is not a complete list of side effects and others may occur. Prescriptionrequired. This is due to lack of specificity of the screening tests. Inside Rx does not guarantee that the price you will pay at the pharmacy will be the same price displayed in advance of purchase. Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Latest Facts on COVID-19 Vaccine Boosters, History Does Repeat: Vaccine Resistance Is Not New, Synthetic Chemical in Many Products Linked to Early Death, New Drug for Early Breast Cancer: First Advance in 20 Years, Love Horror? This information is advisory only and is not intended to replace sound clinical judgment in the delivery of healthcare services. Patients who are pregnant or are allergic to cellulose, citric acid, sodium stearyl fumarate, gelatin, or titanium dioxide should not take Plenity. If you use any over-the-counter (OTC) medicine, including vitamins, herbal or food supplements, be sure to review these products for interactions with your prescription medications, too. Patients who are pregnant or are allergic to cellulose, citric acid, sodium stearyl fumarate, gelatin, or titanium dioxide should not take Plenity. If you have a severe allergic reaction, severe stomach pain, or severe diarrhea, stop using Plenity until you can speak to your doctor. Links to sites outside of Pfizer Medical Information are provided as a resource to the viewer. Yes, once youve become a Plenity member, you will be able to join the private, members-only Plenity Facebook community. A few simple additions or swaps can help you feel fuller and more satisfied. For all medications that should be taken without food (on an empty stomach), continue taking on an empty stomach or as recommended by your physician. Requests for samples of prescription medications can be made by contacting Pfizer for Professionals at 1-800-505-4426 or by visiting the PfizerPro website www.pfizerpro.com. Inside Rx cannot be used with any insurance benefit, copay assistance programs, or by persons covered by state-funded or federal-funded programs such as Medicare, Medicaid, or Tricare for purchases of certain medications, even if processed outside the benefit as an uninsured (cash-paying) patient. Is it available in my area? The recommended dose for PRISTIQ is 50 mg once daily, with or without food. The products discussed herein may have different product labeling in different countries. They will understand the significance of the interaction, and will be able to recommend the next best steps you should take. The INSIDE RX mark is owned by Express Scripts Strategic Development, Inc. Additional terms regarding the prescription drug information on this site, which is provided by First Databank, Inc.: The information contained in the First Databank (FDB) databases is intended to supplement the knowledge of physicians, pharmacists, and other healthcare professionals regarding drug therapy problems and patient counseling information. Disclaimer. Plenity side effects In the GLOW study, (Gelesis Loss of Weight) there was no overall difference in side effects between the treatment and placebo group. The https:// ensures that you are connecting to the Can I use my HSA/FSA/MSA to pay for Plenity? Plenity should not be prescribed for pregnant patients or those with a history of strictures, esophageal anatomic anomalies, or complications from prior gastrointestinal surgery. Most drug interactions listed in package labeling may be theoretical based on a drug's pharmacology. Only FDA approved with a BMI from 25 to 40. Plenity (cellulose and citric acid) is an oral, non-systemic, superabsorbent hydrogel used in conjunction with diet and exercise to aid weight management in adults who are overweight or obese. Plenity is NOT available at retail pharmacies. This may be due to the effect of PRISTIQ on the release of serotonin by platelets. Copyright 2022 by the American Academy of Family Physicians. government site. Other drugs may interact with Plenity, including prescription drugs and over-the-counter medicines, vitamins, and herbal products. Tell your health care provider about all of your medications including any supplements you are taking. Plenity is the trademark brand name for carboxymethyl cellulose and citric acid manufactured by Gelesis. Inside Rx is administered by Inside Rx, LLC, 1 Express Way, St. Louis, MO 63121 . For instance, a person who is 200 lb. Copyright 2022 by RxList Inc. RxList does not provide medical advice, diagnosis or treatment. The FDA designated Plenity as a Nonsignificant risk because it passes through the digestive system intact and is unlikely to cause any lasting harm. To calculate your BMI, divide your weight in pounds (lb.) 2021 Dec 7;8(3):363-370. doi: 10.1002/osp4.574. of water during or immediately after your meal. False positive test results may be expected for several days following discontinuation of desvenlafaxine therapy. Metabolic enzymes in your body and your genetics. Because Plenity should not be used without food (it is meant to be taken 2030 minutes before a meal), this Abstracts and posters were identified from relevant scientific congress archives and published supplements. Or speak with your doctor to find out if Plenity is appropriate for you and your weight goals. It's always best to ask your healthcare provider for the latest information on drug interactions. Plenity costs $98 for a one-month supply. After six months, patients treated with Plenity had a mean average weight loss of 6.4% compared with 4.4% in those receiving placebo. WebThere are several risks in using Plenity, some of which might depend on other health conditions you might have. You do not need to meet with a physician in person to get Plenity! Get everything Plenity offers for just $1.75 per meal. Peds dosing is currently unavailable or not applicable for this drug. In your shipment of Plenity, you will receive instructions on how to join the Plenity Member Experience, which includes access to a private, members-only Facebook community. Plenity is not a drug and is stimulant-free and non-habit forming. Contact a doctor right away if problems occur. Plenity may affect how well your body absorbs other medications. 2023 Jan 5;7:e40062. Alka-Seltzer Plus Maximum Strength Sinus Congestion & Pain PowerF Alka-Seltzer Plus Severe Cold & Cough PowerFast Fizz, Alka-Seltzer Plus Severe Cold & Flu Night, Alka-Seltzer Plus Severe Cold & Flu PowerFast Fizz, Alka-Seltzer Plus Severe Cold PowerFast Fizz, Alka-Seltzer Plus Severe Cold PowerFast Fizz Night, Alka-Seltzer Plus Severe Cold PowerFast Fizz Non-Drowsy, Alka-Seltzer Plus Severe Sinus, Cold & Cough, aluminum acetate topical (modified Burow's solution), aluminum hydroxide/magnesium hydroxide/simethicone, amyl nitrite/sodium nitrite/sodium thiosulfate, antihemophilic factor (factor VIII, human). Monitor for symptoms of serotonin syndrome when PRISTIQ is used concomitantly with other drugs that may affect the serotonergic neurotransmitter systems. No gimmicks, just science-backed resources to help support your weight management journey. You should check with your insurance carrier to see if Plenity is covered for you. Note: Multiple pictures are displayed for those medicines available in different strengths, marketed under different brand names and for medicines manufactured by different pharmaceutical companies. With Plenity, you may find it easier to eat less and feel satisfied within weeks of starting your new routine. 12/2021, https://www.cdc.gov/healthyweight/assessing/bmi/adult_bmi/english_bmi_calculator/bmi_calculator.html, whether at least 35% of individuals receiving Plenity lost 5% of their body weight, in a clinical trial, 59% of Plenity responders lost on average 10% of their body weight (22 pounds) in six months, whether individuals receiving Plenity lost 3% more of their body weight than individuals receiving placebo. These medications may cause some risk when taken together. The following adverse reactions are discussed in greater detail in other sections of the label. It is made from naturally derived building blockscellulose and citric acid. Many people begin to lose weight within the first four weeks of taking Plenity. FDA Approved: Yes (First approved April 12, 2019) It is Table 8: Clinically Important Drug Interactions with PRISTIQ Pristiq Website for Healthcare Professionals. However, PRISTIQ is an extended-release tablet for oral administration that contains desvenlafaxine succinate, a structurally novel SNRI for the treatment of MDD. They generally lessen over time and with proper use of the drug. Recent advances in therapies utilizing superabsorbent hydrogel technology for weight management: A review. Before Plenity is NOT available at retail pharmacies. Things to remember when you fill your prescription. Data sources: Call your doctor for medical advice about side effects. This content is owned by the AAFP. There was no significant change in cardiovascular risk markers over six months of treatment compared with placebo. To get Plenity, visit MyPlenity.com to start an online consultation. Some medications may be better absorbed if taken with food or may have more favorable blood levels if taken with other medications that affect metabolic enzymes. squared, and then multiply by a factor of 703. Not all drug interactions are bad. Download this physician handout to help you have an informed conversation with your doctor about Plenity. 25 mg Tablet: tan, square pyramid tablet debossed with "W" over "25" on the flat side. Pfizer RxPathways connects eligible patients to a range of assistance programs that offer insurance support, co-pay help, and medicines for free or at a savings. Share this list with your doctor, pharmacist, and nurse at each visit so that they can also screen for drug interactions. KERI SEWELL, MD, MPH, AND AFI M. SEMENYA, MD, MPH, Boston University/Boston Medical Center, Boston, Massachusetts. Some mixtures of medications can lead to serious and even fatal consequences. You can either ask your healthcare provider about Plenity, or visit MyPlenity.com to start a telehealth experience with a licensed physician. Plenity may interact with other oral medications taken at the same time. The overall incidence of side effects with Plenity was no different than placebo. Plenity (cellulose and citric acid) Consumer information. The most In a clinical study,* nearly 6 out of 10 people who took Plenity lost at least 5% of their body weight. To avoid impact on the absorption of medications: For all medications that should be taken with food, take them after starting a meal. Body weight management in overweight and obese breast cancer survivors. Plenity costs $98 for a 4-week supply ($1.75 per meal). Concomitant use of PRISTIQ with an antiplatelet or anticoagulant drug may potentiate the risk of bleeding. Learn How Genetics Make Some Fans of Fear, Dr. Whyte's Book: Take Control of Your Cancer Risk, How Breast Cancer Changed My Life and Me, Health News and Information, Delivered to Your Inbox. Based on pharmacokinetic studies, no dosage adjustment is required for drugs that are mainly metabolized by CYP3A4 (e.g., midazolam), or for drugs that are metabolized by both CYP2D6 and CYP3A4 (e.g., tamoxifen, aripiprazole), when administered concomitantly with PRISTIQ [see Clinical Pharmacology (12.3)]. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. Plenity prescriptions can ONLY be filled by GoGoMeds Pharmacy. Rx Only. Web7.3 Alcohol A clinical study has shown that PRISTIQ does not increase the impairment of mental and motor skills caused by ethanol. Last updated by Judith Stewart, BPharm on May 13, 2019. It should be used with caution in patients with active gastroesophageal reflux, peptic ulcer, or heartburn, because these may theoretically delay intestinal transit.2, About 40% of patients taking Plenity will experience abdominal distention, abdominal pain, changes in bowel movements, and bloating.