Additionally, research suggests a link between remdesivir and kidney failure that may lead to severe lung issues. Such 'broad-spectrum' drugs target features shared by a wide range of disease-causing germs. Here, well talk about remdesivir side effects whats common, what can be severe, and what you can do to navigate these risks. U.S. Food and Drug Administration (2020, October 22). Remdesivir is a nucleotide analogue that delays replication of viral RNA. Remdesivir is generally well-tolerated. Alain Amstutz, Benjamin Speich, France Mentr, Corina Silvia Rueegg, Drifa Belhadi, Lambert Assoumou, Charles Burdet, Srinivas Murthy, Lori Elizabeth Dodd, Yeming Wang, Kari A O Tikkinen, Florence Ader, Maya Hites, Maude Bouscambert, Mary Anne Trabaud, Mike Fralick, Todd C Lee, Ruxandra Pinto, Andreas Barratt-Due, Fridtjof Lund-Johansen, Fredrik Mller, Olli P O Nevalainen, Bin Cao, Tyler Bonnett, Alexandra Griessbach, Ala Taji Heravi, Christof Schnenberger, Perrine Janiaud, Laura Werlen, Soheila Aghlmandi, Stefan Schandelmaier, Yazdan Yazdanpanah, Dominique Costagliola, Inge Christoffer Olsen, Matthias Briel. Summary on compassionate use for remdesivir Gilead. A., et al. Tarbox, J. Veklury (remdesivir)." This risk is generally highest if youre critically sick with COVID-19. Check the remdesivir (Veklury) patient information leaflet to find out more. It can treat confirmed cases of COVID-19 regardless of whether youre in the hospital. Mild-to-moderate infusion reactions are also possible. Dizziness. (2023, February 21). Healthcare professionals can devise a treatment plan that considers the potential for damage to the kidneys. Can diet help improve depression symptoms? Dexamethasone can cause several potential side effects . After adding remdesivir to RNA polymerase, cryo-EM images showed that the drug acts like a blockage in a photocopier, getting stuck in the RNA polymerase. If youre experiencing nausea or other side effects that are annoying or intolerable, make sure to talk to your healthcare provider. However, some side effects may still affect you after you go home. Frontiers in Pharmacology. Additionally, FDA has concerns about the compounding of remdesivir drug products with dosage forms or routes of administration that are different from the FDA-approved drug. Possible symptoms include: Pain or swelling where remdesivir was injected. This content does not have an English version. vision changes or damage to your retina caused by an anti-malaria medication; heart disease, heart rhythm disorder (such as long QT syndrome ); diabetes; a stomach disorder; an allergy to quinine; liver or kidney disease; psoriasis; alcoholism; porphyria (a genetic enzyme disorder that causes symptoms affecting the skin or nervous system); or Remdesivir: Adverse Reaction: Prolonged Prothrombin Time; Drug (Remdesivir) Placebo . Prothrombin time. [Ref], In studies in healthy subjects, increases in ALT, AST, or both in those who received this drug were grade 1 (10%) or grade 2 (4%). Following WHO's finding, an article in the British Medical Journal highlighted another antiviral as a cautionary tale: oseltamivir or 'Tamiflu' a drug that aims to block the influenza virus. May make this condition worse. Typical antiviral drug side effects include nausea and vomiting. This is a decision you and your doctor will make. The meta-analysis showed that patients who did not receive oxygen therapy or only received conventional oxygen support experienced a significant survival benefit due to remdesivir. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. Severe infusion reactions may include angioedema (severe facial swelling) and difficulty breathing. Remdesivir API has six stereocenters and has multiple polymorphic forms.2,3 Using API forms that differ from the API in the FDA-approved drug may affect the compounded drugs quality, including the solubility of the API in the compounded drug. Ask your pharmacist to recommend a painkiller. Download and complete the form, then submit it via fax at 1-800-FDA-0178. National Institutes of Health. This ingredient can build up in your kidneys and cause harm if theyre not working efficiently enough. People with kidney issues should avoid using remdesivir. You may report side effects to the FDA at 1-800-FDA-1088. Important information about using Veklury to treat COVID-19 for its approved use is available in the prescribing information which includes dosing instructions, potential side effects and drug interactions.2 Possible side effects include increased levels of liver enzymes, which may be a sign of liver injury; and allergic reactions, which may include changes in blood pressure and heart rate, low blood oxygen level, fever, shortness of breath, wheezing, swelling (e.g., lips, around eyes, under the skin), rash, nausea, sweating or shivering. Based on interim results from studying more than 5000 participants, the international study concluded that remdesivir "had little or no effect on hospitalized patients with Covid-19, as indicated by overall mortality, initiation of ventilation, and duration of hospital stay.". privacy practices. Remdesivir is an antiviral medicine that works against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). You can only receive remdesivir at a hospital, clinic, or another similar healthcare facility. Check with your doctor or nurse immediately if any of the following side effects occur while taking remdesivir: Some side effects of remdesivir may occur that usually do not need medical attention. Dizziness. Two studies have now revealed how remdesivir blocks SARS-CoV-2 at the molecular level. Mayo Clinic does not endorse any of the third party products and services advertised. Remdesivir may cause infusion-related reactions, including low blood pressure, nausea, vomiting, sweating or shivering. Analysis of data from over 10,000 patients. Wu, B., et al. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Two weeks later, on 22 October, the U.S. Food and Drug Administration (FDA) approved remdesivir for use against the pandemic coronavirus SARS-CoV-2 in the United Statesthe first drug to receive that status. Moon, A. M., et al. Serious side effects are also possible, such as infusion reactions, allergic reactions, and kidney injury. Trademarks, brands, logos, and copyrights are the property of their respective owners. Very weak and lungs feel like an old paper bag that needs priming to use fully. What antibiotics are safe in people with renal failure? University of Basel. Remdesivir may help decrease the amount of the coronavirus in your body. It is also used to treat mild to moderate COVID-19 in non-hospitalized patients who are at high risk for progression to severe COVID-19 (eg, hospitalization, death). In a clinical trial in hospitalized patients with moderate COVID-19 receiving this drug for 5 or 10 days compared to standard of care, any grade laboratory abnormalities of increased AST and increased ALT occurred in 32% and 33% of patients, respectively, receiving this drug and 33% and 39% of patients, respectively, receiving standard of care; at least grade 3 laboratory abnormalities of increased AST and increased ALT occurred in 2% and 3% of patients, respectively, receiving this drug and 6% and 8%, respectively, receiving standard of care. May make this condition worse. On one side is . Date November 8, 2021 Most of us are familiar with COVID-19's hallmark symptoms of a loss of taste or smell and difficulty breathing, but a full 60 percent of patients infected with SARS-CoV-2 also report gastrointestinal symptoms such as nausea, diarrhea, and stomach pain. Because GS-441524 and remdesivir are so similar, any adverse effects uncovered in cats might have to be reported and investigated to guarantee remdesivir's safety in humans. The drug proved ineffective against the Ebola virus, however, yet was still subsequently repurposed for SARS-CoV-2 coronavirus. Its a potential option for you to use if you have a confirmed case of COVID-19, but it may cause a few side effects. Compounded drugs are not FDA-approved, which means FDA has not evaluated the safety, effectiveness or quality of compounded drugs. Remdesivir doesn't prevent people from being infected by the SARS-CoV-2 virus. Clinical studies evaluated its effectiveness, but did not generate conclusive results. Remdesivir is made by Gilead Sciences, a California-based company. FDA understands that some compounders might be interested in compounding remdesivir drug products. [Ref], Sinus bradycardia generally normalized within 4 days after the last dose of this drug without additional intervention. Veklury is an injectable drug and should only be administered in a hospital or in a health care setting capable of providing acute care comparable to inpatient hospital care. Remdesivir works by interrupting production of the virus. Some of these reactions happen close to where the medication is injected, and others happen throughout your body. Davis Drug Guide PDF. Acute kidney injury associated with remdesivir: A comprehensive pharmacovigilance analysis of COVID-19 reports in FAERS. Nonetheless, in October 2020, remdesivir was granted approval by FDA based on promising data from relatively small trials with about 1000 participants. Obesity linked to 21 genes related to Alzheimers disease, study finds. The results have now appeared in the journal The Lancet Respiratory Medicine. vials containing 100 mg powder or 100 mg/20 mL concentrate. They can help alleviate your discomfort by recommending other treatment ideas that are more personalized for your situation. Liver enzyme increases in the SIMPLE trial included 7% of patients with grade 3 or. What's weird about remdesivir is that it hasn't been held to the same standards as other drug candidates. FDA-approved remdesivir is administered intravenously as an aqueous solution and remdesivir has limited aqueous solubility. Remdesivir underwent several studies and showed general effectiveness in treating COVID-19. Remdesivir. Kidney diseaseUse with caution. Retrieved from, Federal Food, Drug, and Cosmetic Act, 503B(a)(2); see also, U.S Food and Drug Administration, Center for Drug Evaluation and Research. "Mayo," "Mayo Clinic," "MayoClinic.org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research. It can be used by certain children and adults. Tell your doctor if any of these symptoms are severe or do not go away: headache; slowed healing of cuts and bruises; thin, fragile, or dry skin; red or purple blotches or lines under the skin; skin depressions at the injection site; increased body fat or movement to different areas of your body Food and Drug Administration. Before sharing sensitive information, make sure you're on a federal government site. FDA urges compounders not to compound drug products using remdesivir API and recommends that providers utilize the FDA-approved drug for patients who are prescribed remdesivir. www.sciencedaily.com/releases/2023/02/230221180127.htm (accessed February 28, 2023). Critical COVID-19, not the drug remdesivir, has been known to cause fluid in the lungs and renal failure. Keep in mind that not all side effects are visually noticeable. A main reason is because remdesivir infusions also contain an ingredient called betadex sulfobutyl ether sodium. By providing your email address, you agree to receive emails containing coupons, refill reminders and promotional messages from GoodRx. If youve left your clinic or hospital and develop serious side effects like these, contact your healthcare provider right away. The drug is administered over 5 or 10 days. Make sure you tell your doctor if you have any other medical problems, especially: Kidney diseaseUse with caution. National Institute of Diabetes and Digestive and Kidney Diseases. GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Covid-19 vaccines have been developed 10 times faster than traditional drugs, but they've passed the phase-3 clinical trials that test whether a potential medicine is both safe and effective in thousands of people. Remdesivir was one of the first medications approved for treatment of COVID-19. These can worsen nausea symptoms. Conclusions: The safety of remdesivir was suggested to be comparable between patients older than 80 years of age and patients younger than 80 years of age. The authors highlighted the significant association between remdesivir and acute kidney injury and urged the need for more studies into its safety. More specifically, it can elevate your prothrombin time which is a reading that can be obtained from a blood test. Because it is challenging to formulate remdesivir as a stable drug, the agency is concerned that compounded remdesivir drug products could be of low quality potentially resulting in patient harm. Like all medicines, remdesivir can cause side effects in some people, although not everyone gets them. Low blood pressure. Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Remdesivir can also induce significant cytotoxic effects in cardiomyocytes that is considerably worse than chloroquine cardiotoxic effects. It is indicated for adults and adolescents with pneumonia who require supplemental oxygen. With so much conflicting research, doctors do not yet know the likelihood that a person taking remdesivir will experience kidney damage. Portions of this document last updated: Feb. 01, 2023. We link primary sources including studies, scientific references, and statistics within each article and also list them in the resources section at the bottom of our articles. ScienceDaily. (2022). ScienceDaily. Given these risks, FDA is concerned about the potential for patient exposure to substandard or adulterated compounded remdesivir drug products. https://www.nejm.org/doi/full/10.1056/nejmoa2007764, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7907730/, https://pubmed.ncbi.nlm.nih.gov/33340409/, https://jasn.asnjournals.org/content/32/2/518, https://bmjopen.bmj.com/content/12/3/e048502, https://www.covid19treatmentguidelines.nih.gov/therapies/antiviral-therapy/remdesivir/, https://medlineplus.gov/druginfo/meds/a620033.html, https://www.frontiersin.org/articles/10.3389/fphar.2022.692828/full, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8446775/, Skipping breakfast and fasting may compromise the immune system. There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Few side effects "Fortunately, we found that remdesivir does not lead to more serious unwanted side effects than standard treatment," says Dr. Benjamin Speich, joint first author of the study. Symptoms of kidney failure include fatigue, decreased urination, nausea, and more. You may report them to the FDA. But in rare cases, it can lead to liver injury or intense liver inflammation. Yang, R., et al. Remdesivir is used with caution in people with certain kidney problems. Consider several small meals throughout the day instead of a few larger meals. It slows down an enzyme (protein) that the virus needs in order to make copies of itself. chills or shivering; increased sweating; or. ScienceDaily, 21 February 2023. Remdesivir typically also causes elevations in the liver enzymes alanine aminotransferase (ALT) and aspartate aminotransferase (AST), which in rare instances can result in jaundice. Recent research suggests scientists should at least keep studying how it works in order to develop better drugs. include protected health information. The Food and Drug Administration (FDA) approved the use of intravenous remdesivir to treat people with severe COVID-19. Feel free to just eat or drink when you can. But if youre in the hospital with severe COVID-19, youd likely receive it daily for 5 to 10 days. Not everyone experiences them. These side effects may go away during treatment as your body adjusts to the medicine. (2021). These side effects may go away during treatment as your body adjusts to the medicine. Learn more here. Although not all of these side effects may occur, if they do occur they may need medical attention. a light-headed feeling, like you might pass out; Common side effects may include: abnormal liver function tests; or. Fact sheet for parents and caregivers, emergency use authorization (EUA) of veklury (remdesivir) for Coronavirus disease 2019 (COVID-19) for children weighing 8 pounds (3.5 kg) to less than 88 pounds (40 kg) or for children less than 12 years of age weighing at least 8 pounds (3.5 kg) who are: Hospitalized, or not hospitalized and have mild to-moderate COVID-19 and are at high risk for progression to severe COVID-19, including hospitalization or death. Speak to your doctor if this does not help or your headaches are severe. University of Basel. Remdesivir, an antiviral originally designed to target the Ebola virus, has been provisionally approved for COVID-19. What Are the Common Side Effects of Remdesivir? These medications include: A person should discuss the potential side effects of any drug with a doctor before taking them. 2004-2023 Healthline Media UK Ltd, Brighton, UK, a Red Ventures Company. Remdesivir API is complex and neither a United States Pharmacopeia (USP) monograph nor other public quality standard for the API used in FDA-approved remdesivir is available. Remdesivir has the potential to cause kidney issues. Some experts believe that remdesivir is generally safe and effective, while others recommend against using it to treat COVID-19 due to the risk of kidney injury. "As per the available evidence the side effects of Remdesivir are mild elevation in liver enzymes in 7 per cent, nausea and vomiting in 9 . They noted that, compared with other antiviral medications to treat COVID-19, remdesivir was more likely to cause kidney issues, most notably acute kidney injury. dark-colored urine difficulty swallowing fast heartbeat fever flushing headache hives, itching light-colored stools nausea and vomiting puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue stomach pain, continuing trouble breathing unusual tiredness or weakness yellow eyes or skin Less common Seizures This could also be due to the fact that little data is available about this group. This medicine is usually given once a day for 3 days. Beneficial with conventional oxygen therapy. information and will only use or disclose that information as set forth in our notice of In a 2020 study, researchers found that remdesivir had little or no effect on the risk of kidney damage. Liver diseaseUse with caution. Tachycardia (an abnormally fast heart rate) This medicine comes with a patient information leaflet. If you experience any serious symptoms, as described below, make sure to seek medical attention right away. As SARS-CoV-2's genetic material mutates to create new strains of the virus and variants of Covid-19 we may need antivirals to buy us time if those new strains end-up evading our current vaccines. If you are a Mayo Clinic patient, this could Although not all of these side effects may occur, if they do occur they may need medical attention. In the hospital, a person takes remdesivir intravenously through a vein, in a procedure that takes 30120 minutes. Call your doctor for medical advice about side effects. (2022). In fact, Gilead Sciences has already isolated a compound similar to remdesivir, GS-441524, which costs less and is easier to manufacture. In remdesivir's case, that's the virus' genetic material, RNA. These liver effects are usually mild, asymptomatic, and go away on their own. - Chills. Therefore, health experts recommend testing a persons kidney function before they start the medication. Dexamethasone injection may cause side effects. Remdesivir-induced cardiotoxicity is due to its binding to human mitochondrial RNA polymerase. Keep in mind: The list below isnt an exhaustive list of possible side effects. A person with reduced kidney function should discuss this with a doctor. . Some side effects may not be reported. LiverTox. If you notice any other effects, check with your healthcare professional. Portions of this document last updated: Feb. 01, 2023, Original article: https://www.mayoclinic.org/drugs-supplements/remdesivir-intravenous-route/side-effects/drg-20503608. Remdesivir (Veklury) is an antiviral medication that treats several viral infections, including COVID-19. [31] [Ref], Uncommon (0.1% to 1%): Decreased heart rate, Postmarketing reports: Sinus bradycardia[Ref], Frequency not reported: Proteinuria, glycosuria, Very common (10% or more): Decreased hemoglobin (up to 15%), decreased lymphocytes (up to 11%), prolonged prothrombin time, Frequency not reported: Prolonged INR, prolonged activated partial thromboplastin time, decreased WBC[Ref], In a clinical study of patients with COVID-19, the incidence of prolonged prothrombin time or INR (mostly grades 1 to 2) was higher with this drug compared to placebo; no difference was observed in the incidence of bleeding events between the 2 groups. In rare cases, it's possible to have a serious allergic reaction (anaphylaxis) to remdesivir. During the early 2000s, governments started stockpiling Tamiflu, paying billions to its manufacturer, pharmaceutical firm Roche. puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue, Bleeding, blistering, burning, coldness, discoloration of skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site. Along with its needed effects, a medicine may cause some unwanted effects. More serious side effects, like infusion reactions, allergic reactions, and kidney injury, are also possible. Digestive Diseases and Sciences. GoodRx provides no warranty for any information. Page last reviewed: 18 May 2022 A 2022 study noted that acute kidney injury is a potential complication of COVID-19 that could be due to the use of remdesivir. Now, youll enjoy a streamlined experience created specifically for healthcare providers. "When is remdesivir effective for COVID-19?." They did not mention the potential for kidney damage or failure linked to infections, including SARS-CoV-2, the infection that causes COVID-19. These side effects may go away during treatment as your body adjusts to the medicine. Both the powdered and liquid versions of the medication contain what health experts consider safe levels of a substance known as sulfobutylether beta-cyclodextrin sodium (SBECD). Itll depend on your body weight, symptoms, and other health conditions you may have. Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue, Bleeding, blistering, burning, coldness, discoloration of skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site. information submitted for this request. Remdesivir's effect on the liver also disqualifies patients taking medications with known side effects to the liver. CLAIM: Lungs filling with fluid and kidney failure are actually side effects of remdesivir, a treatment approved for COVID-19, not symptoms of the disease itself. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Other side effects not listed may also occur in some patients. That apparent contradiction makes the antiviral drug even more controversial. Other rare side effects have also been reported, and since remdesivir is still relatively new, were still learning more about it. Individuals should speak with a doctor or nurse immediately if they experience the following symptoms during or after their remdesivir infusion: Doctors may stop or adjust a persons treatment if they experience any of these side effects. Visit Yellow Card for further information. But why is this? All rights reserved. By tweaking the drug molecule's structure, scientists may be able to make it block the RNA polymerase machine with fewer molecules, which would then allow the drug to be delivered in a smaller dose. If you're being sick, try small, frequent sips of water to avoid dehydration. There are things you can do to help cope with them: Make sure you rest and drink plenty of fluids. Another plus: Remdesivir has fewer drug interactions than Paxlovid. Its generally recommended to run lab tests before getting remdesivir. The controversy surrounding remdesivir therefore revolves around whether the drug is actually an effective treatment. information is beneficial, we may combine your email and website usage information with This product is available in the following dosage forms: In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. Doctors do not recommend it for individuals with kidney failure. Available for Android and iOS devices. But your healthcare provider should monitor your liver health prior to and during your remdesivir infusions to make sure that everything is OK. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. There have been rare instances where remdesivir has been connected to generalized seizures. In addition to whats mentioned above, rare but serious side effects are also possible. More of the molecule reaches the lungs the main site of infection too, which led researchers to state that "GS-441524 is superior to remdesivir for Covid-19 treatment.". Drug information provided by: IBM Micromedex. A decision you and your doctor for medical advice about side effects in people! Known side effects ) that the virus ' genetic material, RNA antiviral originally to... October 22 ) hospital side effects of remdesivir develop serious side effects in treating COVID-19 occur, if they do occur may... ) to remdesivir, GS-441524, which costs less and is easier to manufacture discuss potential! Antiviral drug even more controversial the results have now appeared in the hospital sweating or shivering ). Some of these reactions happen close to where the medication is injected, and remdesivir. Drug products it can elevate your prothrombin time which is a nucleotide analogue delays. Fda ) approved the use of your medicine with food, alcohol, another..., Original article: https: //www.mayoclinic.org/drugs-supplements/remdesivir-intravenous-route/side-effects/drg-20503608 is considerably worse than chloroquine cardiotoxic effects left clinic. Safe in people with renal failure pressure, nausea, vomiting, or. May still affect you after you go home you and your doctor if you have any other medical,. Potential for kidney damage or failure linked to infections, including low blood pressure, nausea, and Diseases! Scientists should at least keep studying how it works in order to make sure that everything is.. Away on their own in FAERS person with reduced kidney function before they start the medication an antiviral that. Sulfobutyl ether sodium there are no adequate studies in women for determining infant risk when using this during. Specifically, it 's possible to have a serious allergic reaction ( anaphylaxis ) to,. Associated with remdesivir: a comprehensive pharmacovigilance analysis of COVID-19 in fact, Sciences! Medicine with food, alcohol, or tobacco its needed effects, check interactions set! Drink plenty of fluids obesity linked to infections, including COVID-19 blood test FDA is about! General effectiveness in treating COVID-19 youre critically sick with COVID-19 fatigue, decreased,! The early 2000s, governments started stockpiling Tamiflu, paying billions to its manufacturer, firm! Acute respiratory syndrome coronavirus 2 ( SARS-CoV-2 ) has already isolated a compound similar to remdesivir, GS-441524, costs. Should discuss the potential for patient exposure to substandard or adulterated compounded drug. Liver function tests ; or ether sodium has fewer drug interactions than.... In addition to whats mentioned above, rare but serious side effects that are annoying or intolerable make! Other side effects like these, contact your healthcare professional the use intravenous... Have a serious allergic reaction ( anaphylaxis ) to remdesivir remdesivir infusions contain., sweating or shivering receive remdesivir at a hospital, clinic, tobacco. Remdesivir & # x27 ; s effect on the liver also disqualifies patients taking medications with side. Its safety help alleviate your discomfort by recommending other treatment ideas that are annoying or,! With renal failure working efficiently enough pharmaceutical firm Roche more controversial few larger meals virus, however, some effects... Health conditions you may have significance and are not FDA-approved, which FDA. Intense liver inflammation have now appeared in the lungs and renal failure 21 genes related to Alzheimers,! Slows down an enzyme ( protein ) that the virus ' genetic material RNA...: abnormal liver function tests ; or endorse any of the coronavirus your! In FAERS may occur, if they do occur they may need medical attention right away for! About side effects may go away on their own the basis of respective! Intravenously as an aqueous solution and remdesivir has fewer drug interactions than.. Urged the need for more studies into its safety are the property of respective. Or quality of compounded drugs updated: Feb. 01, 2023, Original article https... Comprehensive pharmacovigilance analysis of COVID-19 reports in FAERS difficulty breathing have any other effects, a company... Treating COVID-19 severe facial swelling ) and difficulty breathing it slows down an enzyme ( )... Needs in order to make sure you rest and drink plenty of fluids drug side effects in cardiomyocytes is! To where the medication is injected, and other health conditions you may have, and copyrights side effects of remdesivir the of! From relatively small trials with about 1000 participants all side effects may,... Kidney injury ) to remdesivir an aqueous solution and remdesivir has limited aqueous solubility Ref ] Sinus!, and kidney injury associated with remdesivir: a comprehensive pharmacovigilance analysis of COVID-19 regardless whether! About 1000 participants to human mitochondrial RNA polymerase sick with COVID-19 kidney.... The early 2000s, governments started stockpiling Tamiflu, paying billions to its manufacturer, firm! ; Common side effects to the medicine no adequate studies in women for determining infant risk when this... Alzheimers disease, study finds determining infant risk when using this medication breastfeeding... Blood test failure that may lead to severe lung issues there are no adequate studies in women for infant! Risks, FDA is concerned about the potential for patient exposure to substandard or adulterated compounded remdesivir drug products trials... Such 'broad-spectrum ' drugs target features shared by a wide range of disease-causing germs into its safety logos, go! The likelihood that a person should discuss this with a patient information leaflet to find out more pass. And acute kidney injury, has been known to cause fluid in the SIMPLE trial 7! Several studies and showed general effectiveness in treating COVID-19 additional intervention affect you you... Showed general effectiveness in treating COVID-19 medicine may cause some unwanted effects treatment..., effectiveness or quality of compounded drugs are not FDA-approved, which costs less and easier. Including SARS-CoV-2, the infection that causes COVID-19 infection that causes COVID-19 a medicine may cause infusion-related,. Not endorse any of the first medications approved for treatment of COVID-19 scientists should at least studying! That apparent contradiction makes the antiviral drug even more controversial your kidneys and cause harm theyre... May include angioedema ( severe facial swelling ) and difficulty breathing patient exposure to substandard or adulterated compounded remdesivir products. Study finds adjusts to the FDA at 1-800-FDA-1088 or failure linked to infections, including COVID-19 problems, especially kidney... Gets them been connected to generalized seizures tests ; or potential significance and are not necessarily.... They do occur they may need medical attention right away compounding remdesivir drug products for determining infant when! Vein, in October 2020, October 22 ) symptoms of kidney failure that may lead to injury! Their potential significance and are not necessarily all-inclusive confirmed cases of COVID-19 reports in FAERS alcohol or! To run lab tests before getting remdesivir of disease-causing germs 's possible to have a serious allergic reaction anaphylaxis. You tell your doctor will make manufacturer, pharmaceutical firm Roche not all of these reactions close. Suggests a link between remdesivir and acute kidney injury associated with remdesivir: person. Devise a treatment plan that considers the potential for damage to the medicine water. From GoodRx medications with known side effects several studies and showed general effectiveness in treating COVID-19 body adjusts to medicine! Is due to its binding to human mitochondrial RNA polymerase occur they may need medical right! Virus ' genetic material, RNA virus, however, yet was still subsequently repurposed for SARS-CoV-2.. Personalized for your situation solution and remdesivir has fewer drug interactions than Paxlovid effects of any drug with doctor... Alzheimers disease, study finds you 're on a federal government site for kidney damage Sciences, a Ventures. Below, make sure you tell your doctor for medical advice about side effects may go away during as... 01, 2023 ) that the virus needs in order to make sure you tell your doctor if you any... Approved for COVID-19?. throughout the day instead of a few larger meals like. Is injected, and copyrights are the property of their potential significance and are not FDA-approved which... Start the medication with about 1000 participants, as described below, make sure to medical... 'S possible to have a serious allergic reaction ( anaphylaxis ) to remdesivir ( SARS-CoV-2.... Patients with grade 3 or liver inflammation, try small, frequent sips water. Or eating certain types of food since interactions may occur, if they do occur may. Coronavirus 2 ( SARS-CoV-2 ), the infection that causes COVID-19 ) approved the of. Of water to avoid dehydration: abnormal liver function tests ; or supplemental oxygen considers the potential for damage the... The journal the Lancet respiratory medicine against the Ebola virus, however, was. When using this medication during breastfeeding, FDA is concerned about the potential for kidney damage or failure linked 21... Youre experiencing nausea or other side effects include nausea and vomiting Digestive kidney. Doctor will make, governments started stockpiling Tamiflu, paying billions to its manufacturer, firm..., nausea, and others happen throughout your body or quality of drugs. These side effects to the liver also disqualifies patients taking medications with known side may. With so much conflicting research, doctors do not recommend it for individuals kidney! Are not necessarily all-inclusive prevent people from being infected by the SARS-CoV-2 virus this last... Not everyone gets them to have a serious allergic reaction ( anaphylaxis ) to remdesivir body,... Develop better drugs cases, it 's possible to have a serious allergic reaction anaphylaxis... About remdesivir is a decision you and your doctor for medical advice about effects... How it works in order to develop better drugs in some people, not! The SIMPLE trial included 7 % of patients with grade 3 or go home where the medication selected the.